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CD57 Blood Test for Lyme Disease

HNK1 (CD57) lymphocyte subset Lyme
Sample Report
Specimen Type: Blood


CD57 Blood Test for Lyme Disease

The Lyme Disease CD57 HNK1 test is used to aid in the diagnosis of Lyme Disease as well as to monitor treatment.  Lyme Disease tends to suppress a person's immune system and many people with Lyme have shown a low count for the CD57 Lymphocyte.  Typically a CD57 count below 60 is indicative of Lyme Disease.  In people being treated for Lyme Disease, monitoring their CD57 count can help determine how well they are responding to treatment.  This test can be used as a screening, however not all Lyme people will show a lowered CD57 count and some conditions besides Lyme may lower this count as well.  Confirmation with a Western Blot test is recommended. 

This test includes a complimentary CBC (Complete Blood Count).

Lyme Disease is caused by infection with the bacteria Borrelia burgdorferi.  It is most commonly spread by the Deer Tick or Black Legged Tick and is the most common tick-borne illness in the United States and Europe.  Lyme disease can be difficult to diagnose because the symptoms are often similar to other afflictions.  While some people will display a distinctive "bulls-eye" rash around the site of the bite, others may experience common flu-like symptoms such as fever, chills, fatigue, and headache.  The ticks which spread the disease are typically very small (the size of a pin head) and many people do not even realize they have been bitten.  If left untreated, Lyme Disease can cause joint pain, numbness in the arms and legs, facial paralysis, Meningitis, heart problems, or memory problems.

Testing for Lyme Disease is advised when a person is experiencing symptoms associated with Lyme, especially if they have had a recent tick bite or have been in an area where Lyme Disease is prevalent.  Testing should also be considered by anyone who has been in an area where Deer Ticks are known to be common.  A CD57 HNK1 test is usually ordered to monitor treatment in people with Lyme disease.  This test can be ordered to screen for Lyme Disease, however antibody testing such as the Total and IgM Abs test is more commonly ordered.  A CD57 test may be useful for people who suspect they have been exposed to Lyme Disease but are receiving inconclusive results from antibody testing.   

Turnaround time for the Lyme Disease CD57 HNK1 is typically 1-3 business days.

Note: Result turn around times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Incubation Period:

The amount of time time it takes for a person's immune sytem to be affected by Lyme Disease is variable.  It is recommended that a person consult their doctor to determine if this test is relevant for their situation.



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