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Creatinine Clearance (24 Hour Urine and Blood) Test

Clearance, Creatinine
Sample Report
Specimen Types: Blood,Urine


Creatinine Clearance (24 Hour Urine and Blood) Test

This test measures Creatinine levels in both the blood and a 24 hour urine sample.  Results will provide measurements for serum creatinine, urine creatinine, 24 hour urine creatinine, eGFR and creatinine clearance.  Creatinine is a waste product produced by the breakdown of creatine in the muscles.  Because creatinine is normally excreted from the body through the kidneys, measuring creatinine levels is a way of evaluating kidney function.  The creatinine clearance test can help determine the rate at which blood is being carried to the kidneys as well as how well the kidneys are filtering waste products like creatinine. 

This test includes Estimated Glomerular Filtration Rate (eGFR). EGFR is calculated based on a person's creatinine levels. It is an estimate of how much blood per minute is being filtered by the kidneys. A decline in kidney function causes lowered eGFR which can lead to the buildup of waste products in the blood.

The Creatinine Clearance test is typically ordered as a follow up to abnormal results on tests such as Blood Creatinine, Comprehensive Metabolic Panel (CMP) or Complete Urinalysis or when someone is experiencing symptoms of a kidney disorder.  This test can also be used to monitor people with kidney disease or congestive heart failure. 

Turnaround time for the Creatinine Clearance test is typically 1-3 business days.

Note: Result turn around times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.


The Creatinine Clearance (24-hour Urine and Serum) test is both a blood and urine collection. The blood test has no fasting requirements but is preferably collected at the time the urine collection is completed. The Creatinine, 24-hour Urine test requires people void urine at 8am and discard the specimen. Then collect all urine in 24-hour period, ending with final collection at 8am the next morning.

It is important to stay hydrated during the period of specimen collection.

Exercise should be avoided prior to and during the period of specimen collection. 

Certain medications may interfere with the results of this test.  Customers should connect with a prescribing physician to determine if they should stop taking medication prior to specimen collection.



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