What is GLP-1?

Glucagon-like peptide-1 or GLP-1 is a hormone that helps regulate blood sugar, digestion, and appetite.  Synthetic versions of GLP-1 are used as medications to help treat type 2 diabetes and obesity.  GLP-1 agonists have recently been making headlines due to a rise in popularity as weight loss agents. These drugs are extremely effective for blood glucose control and weight management, which, combined with their limited side effects, makes them very appealing. Researchers are still learning about other potential uses and benefits of the GLP-1 agonist medications. 

GLP-1 medications are relatively new. The U.S. Food and Drug Administration (FDA) approved the first GLP-1 agonist in 2005. The medicines are most often injectable, meaning you inject a liquid medication with a needle and syringe. Today, they are approved for use in treating type 2 diabetes and treating obesity with associated related conditions. The FDA has not approved GLP-1 agonists for treating type 1 diabetes.

Does GLP-1 help with diabetes and weight loss?

GLP-1 drugs help regulate blood glucose and insulin levels. Generally, they are used to treat type 2 diabetes, especially for patients with a high risk of heart failure or atherosclerotic cardiovascular disease. The most effective management of type 2 diabetes involves setting up a treatment plan checking several areas such as lifestyle and diet, exercise, and medications.

With groundbreaking drugs revolutionizing chronic weight management, GLP-1s have transformed the way healthcare providers are tackling the obesity pandemic. Most patients with obesity should have blood tests done to assess their overall health and obesity-related conditions. The medical tests should be repeated intermittently to check the weight loss progress and health of the patient. There’s no “best” way to manage Type 2 diabetes or obesity. Every person is unique and so is each treatment plan.

What should you consider before taking GLP-1 medication?

If you are considering being treated with GLP agonists you should set up an appointment with your healthcare provider to gather as much information as possible about your condition. Ask your doctor about potential benefits and risks. Make sure to inform your doctor of all medications and supplements you are currently taking to avoid interactions. GLP-1 agonists can’t treat type 2 diabetes or obesity by themselves. Both conditions require other treatment strategies, like lifestyle and dietary changes, exercise, and medications.

You will need to understand how often you need to watch blood sugar levels (if applicable) and what types of follow-up appointments you'll need.  Be prepared to incorporate diet and exercise changes, as these are typically important complements to medication therapy.

GLP-1 therapies for diabetes management generally do not mandate routine lab tests but people taking GLP-1 are often recommended to monitor certain levels in their blood. Individualized healthcare approaches may lead to specific recommendations based on a patient's unique health profile. Tests should be taken prior to starting medication to establish baseline levels or during treatment and discussed with your doctor, especially if any of the results are outside of the expected range.

What labs should I take before starting GLP-1 Therapy

Periodic lab testing is advised to watch the effectiveness of GLP-1 therapies and ensure the patient's overall well-being. Before starting GLP-1 agonist therapy certain medical tests and evaluations are typically recommended to ensure safety and effectiveness. Some of the common blood tests include:

• Blood Glucose Levels to assess baseline blood sugar control.
• Kidney Function tests evaluate kidney health, as GLP-1 therapy can be affected by renal function.
• Liver Function tests to ensure that liver health is adequate, as some GLP-1 agonists can have effects on the liver.
• Thyroid Function tests to rule out any thyroid disorders, especially given the concern for potential thyroid tumors in patients receiving GLP-1 therapy.
• A lipid or cholesterol panel measures several types of fats in your blood that can contribute to diabetes, obesity, and heart disease.

Other types of testing can include:

• Pancreatitis History Assessment to provide a thorough history on any previous episodes of pancreatitis, as there may be a risk associated with GLP-1 therapy.
• Cardiovascular Evaluation to assess risk factors for cardiovascular disease, especially if you have a history of heart issues, as some GLP-1 medications have cardiovascular benefits.
• Gastrointestinal Assessment Evaluation for any prior gastrointestinal issues, as GLP-1 therapy can affect gastric motility.

Always consult with your healthcare provider to figure out the specific tests you may need based on your individual health history and conditions. They will be able to provide personalized guidance and recommendations. Having all this information can help you make an informed decision and better manage your health with GLP-1 therapy.

Where can I get GLP-1 Blood Tests Near Me?

Request A Test offers lab testing that anyone can order.  We don't require a doctor's visit or insurance.  Just order the tests you need and go to one of the over 7,000 testing locations we work with.  Our menu includes hundreds of options including a GLP-1 blood testing panel.  This package includes a variety of tests that can help monitor the effectiveness of GLP-1 therapy.

• Complete Blood Count (CBC): Includes white and red blood cells, hemoglobin, hematocrits, platelets, and more.
• Comprehensive Metabolic Panel (CMP): measures blood sugar, liver enzymes, kidney function, and more.
• Hemoglobin A1C: Your average blood sugar level over several months
• Insulin: An important marker for diabetic control
• Lipid Panel (Cholesterol): Includes total cholesterol, HDL, LDL, and triglycerides.
• Thyroid Stimulating Hormone (TSH): The most common measure for thyroid function

To order your testing, just visit our website or contact our team at 888-732-2348.  We are committed to helping as many people as possible take charge of their health journey.

Sources: 

GLP-1 Agonists: What They Are, How They Work & Side Effects

Considering GLP-1s: A Guide to Deciding If It's Right for You

Considering GLP-1 medications? What they are and why lifestyle change is key to sustained weight loss | Mayo Clinic Diet

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