PHI Test (Prostate Health Index)

Sample Report Test Code: 140405 Specimen Type: Blood

Description:

Prostate Health Index PHI

What is PHI?

The Prostate Health Index (PHI) test can be used to aid in evaluating a person's risk of clinically significant prostate cancer.  In some cases, it may help to avoid the need for a biopsy in someone with elevated PSA levels.  The Prostate Health Index or PHI score is calculated from the results of 3 blood tests: prostate-specific antigen (PSA), Free PSA, and p2PSA.  The PHI score provides a more accurate assessment of an individual's risk of clinically significant prostate cancer, but not their likelihood of developing prostate cancer.  Besides cancer, conditions that can elevate PSA include aging, infection or inflammation of the prostate gland, enlarged prostate, or benign prostatic hyperplasia.

What does the PHI test include?

This test begins with an initial PSA blood level.

• If the PSA level is within the normal reference range of 0.0-3.9, no additional testing will be performed. 
• If the PSA level is between 4.0-10.0, then reflex testing of free PSA and p2PSA, along with calculation of the PHI score and percent free PSA, will be performed at no additional cost.
• If the PSA level is above 10.0, no additional testing will be performed.

Who should order a PHI test?

PHI is most often ordered by people age 50 or older, especially if they have had elevated PSA levels or other risk factors such as a family history of prostate cancer.  While the PSA test has been historically used as a screening tool for prostate cancer, it has been shown to have a limited specificity.  This has led to unnecessary concern for individuals whose PSA is elevated by conditions other than prostate cancer.  The PHI test has a greater level of accuracy and specificity than other types of blood tests.  

Why order a PHI test?

The PHI test can minimize the occurrence of false positives, which can, in turn, reduce the need for unnecessary biopsies, which can be costly, invasive, and uncomfortable.  The PHI test can help aid in the early identification of prostate cancer, which can lead to timely intervention and a better prognosis.  It is important to note that the PHI test can neither diagnose nor rule out prostate cancer by itself.  The results of this test should be reviewed by your doctor to determine the appropriate follow-up.

For the most accurate results, this test should not be performed immediately after a digital rectal exam or within 6 weeks of a prostatic biopsy.

Where can I find a PHI test near me?

Check our lab finder to locate a collection site in your area.

Turnaround for the PHI blood test is typically 3-7 business days.