AChR (Acetylcholine Receptor) Binding Antibody Blood Test
Test Code: 085902
Specimen Type: Blood
AChR (Acetylcholine Receptor) Binding Antibody Blood Test (Labcorp)
This test measures the level of Acetylcholine Receptor (ACHR) Binding Antibodies in the blood. ACHR antibodies are a type of autoantibody produced by the immune system which mistakenly targets proteins in the muscles. These proteins, called acetylcholine receptors, allow communication between nerve and muscle fibers. Damage to these proteins caused by ACHR antibodies can cause muscle fatigue. ACHR antibodies are associated with the autoimmune disorder Myasthenia Gravis (MG). People with myasthenia gravis typically experience symptoms such as drooping eyelids, slurred speech, difficulty holding up their head, difficulty breathing, difficulty walking, and weakness in muscles throughout the body.
There are 3 types of ACHR antibodies that each affect the receptor proteins in different ways. Binding antibodies are the most common, being found in 85-90% of people with MG. They attach to nerve cells and cause an inflammatory response which damages or destroys the receptors. The other 2 types are Blocking and Modulating antibodies.
Testing for ACHR binding antibodies may be ordered when a person is experiencing common symptoms of myasthenia gravis. Results can help to diagnose MG or differentiate it from other conditions with similar symptoms. A Myasthenia Gravis Panel which looks at all 3 types of AChR antibodies is also available.
Turnaround for this test is typically 3-5 business days.
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