AChR (Acetylcholine Receptor) Modulating Antibody Test
Acetylcholine Receptor, Myasthenia Gravis
Test Code: 26474
Specimen Type: Blood
AChR (Acetylcholine Receptor) Modulating Antibody Test (Quest)
This test measures the level of Acetylcholine Receptor (ACHR) Modulating Antibodies in the blood. ACHR antibodies are a type of autoantibody produced by the immune system which mistakenly targets proteins in the muscles. These proteins, called acetylcholine receptors, allow communication between nerve and muscle fibers. Damage to these proteins caused by ACHR antibodies can cause muscle fatigue. ACHR antibodies are associated with the autoimmune disorder Myasthenia Gravis (MG). People with myasthenia gravis typically experience symptoms such as drooping eyelids, slurred speech, difficulty holding up their head, difficulty breathing, difficulty walking, and weakness in muscles throughout the body.
There are 3 types of ACHR antibodies that each affect the receptor proteins in different ways. Modulating antibodies bond with AChR molecules on the muscle surface and cause the receptors to degrade. The other 2 types are Binding and Blocking antibodies.
Testing for ACHR modulating antibodies may be ordered when a person is experiencing common symptoms of myasthenia gravis. Results can help to diagnose MG or differentiate it from other conditions with similar symptoms. A modulating antibody test is not commonly ordered by itself. It is more useful when measured with other ACHR antibody types. A Myasthenia Gravis Panel which looks at all 3 types of AChR antibodies is also available.
Turnaround for this test is typically 4-10 business days.
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Note: Result turn around times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.