Centromere B Antibody Test

Anticentromere B


Test Code: 164814
Specimen Type: Blood

Description:

Centromere B Antibody Test

This test measures the level of anticentromere B antibodies in a blood sample.  Centromere B antibodies are a type of antinuclear antibody which are typically found in people with CREST syndrome.  CREST syndrome is a form of scleroderma, a connective tissue disease.  CREST is named for the primary symptoms that it causes.

  • Calcinosis – Calcium deposits forming under the skin
  • Raynaud phenomenon – Decreased circulation in the fingers and toes, causing them to turn white and blue
  • Esophageal dysfunction – Difficulty swallowing, acid reflux, and heartburn
  • Sclerodactyly – Tight, thick, shiny skin developing on the hands and fingers
  • Telangiectasia – Red spots that appear on the skin due to swollen capillaries

As much as 95% of people with CREST syndrome will test positive for centromere B antibodies.  People with other forms of scleroderma as well as conditions such as cirrhosis, rheumatoid arthritis, and lupus have also been shown to produce centromere B antibodies.  Centromere B antibody testing can aid in diagnosing CREST syndrome as well as differentiating it from other autoimmune disorders with similar symptoms.

This test may be ordered as a follow-up to a positive result on an antinuclear antibody (ANA) test, especially if someone has one or more symptoms of CREST syndrome.  

Turnaround for this test is typically 2-4 business days.

Note: Result turn around times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Categories:


Centromere B Antibody Test

Anticentromere B


Test Code: 16088
Specimen Type: Blood

Description:

Centromere B Antibody Test

This test measures the level of anticentromere B antibodies in a blood sample.  Centromere B antibodies are a type of antinuclear antibody which are typically found in people with CREST syndrome.  CREST syndrome is a form of scleroderma, a connective tissue disease.  CREST is named for the primary symptoms that it causes.

  • Calcinosis – Calcium deposits forming under the skin
  • Raynaud phenomenon – Decreased circulation in the fingers and toes, causing them to turn white and blue
  • Esophageal dysfunction – Difficulty swallowing, acid reflux, and heartburn
  • Sclerodactyly – Tight, thick, shiny skin developing on the hands and fingers
  • Telangiectasia – Red spots that appear on the skin due to swollen capillaries

As much as 95% of people with CREST syndrome will test positive for centromere B antibodies.  People with other forms of scleroderma as well as conditions such as cirrhosis, rheumatoid arthritis, and lupus have also been shown to produce centromere B antibodies.  Centromere B antibody testing can aid in diagnosing CREST syndrome as well as differentiating it from other autoimmune disorders with similar symptoms.

This test may be ordered as a follow-up to a positive result on an antinuclear antibody (ANA) test, especially if someone has one or more symptoms of CREST syndrome.  

Turnaround for this test is typically 3-6 business days.

Note: Result turn around times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Categories: