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Tissue Transglutaminase, IgG Testing

tTG, IgG
Sample Report
Specimen Type: Blood


Tissue Transglutaminase (tTG) testing is used to aid in the diagnosis of Celiac Disease or other conditions related to gluten sensitivity such as Dermatitis Herpetiformis.  There are two types of tTG antibodies which typically devleop is people with Celiac Disease, IgA and IgG.  This test looks for IgG antibodies only.  Tissue Transglutaminase testing is one of the most common Celiac screenings and is often one of the first blood test ordered during testing.

Celiac Disease testing is advisable for anyone who is experiencing symptoms or knows of a family member who has had a positive diagnosis for Celiac.

A Tissue Transglutaminase IgG test is often ordered with a Tissue Transglutaminase IgA test.  Both tTG antibody tests can be ordered together in the Tissue Transglutaminase IgA & IgG package.  IgG testing can be ordered as an alternative for people who have a condition which results in a deficiency of IgA antibodies.  In these cases, an IgA test may show a false negative and an IgG test can be more accurate.  This test is often ordered as part of an initial screening for Celiac Disease.  Because tTG antibody levels usually drop after treatment, this test is also useful for seeing if treatment for Celiac has been successful.

A final diagnosis for Celiac Disease should be confirmed by a doctor and may require additional testing or an intestinal biopsy.  For more information on Celiac Disease testing, please visit the Celiac Disease Foundation at

Turnaround time fo Tissue Transglutminase IgG test is typically 1-2 business days.

Note: Result turn around times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

Incubation Period:


This tTG IgG test has no fasting requirements. Please note it is recommended that prior to taking this test, a regular diet including items that contain gluten should be followed for 2 weeks as a gluten-free diet may not provide an accurate representation of potential gluten sensitivity.

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