Hemoglobin Electrophoresis Thalassemia Blood test
Hemoglobin Electrophoresis Blood Test
The Hemoglobin Electrophoresis test is used to detect and quantify both normal and abnormal forms of Hemoglobin. Hemoglobin is a protein in red blood cells which helps transport oxygen. Measuring hemoglobin variants can help identify a number of inherited conditions which cause a person's body to produce unusually low amounts or irregular types of hemoglobin. Results from this test can aid in diagnosing conditions such as Thalassemia in which a person's body is not producing enough hemoglobin. It can also help to identify conditions such as Sickle Cell Disease.
This test includes measurements for:
- Hemoglobin F: Fetal Hemoglobin. Normal hemoglobin type which typically makes up less than 2% of hemoglobin in adults
- Hemoglobin A: Normal hemoglobin type which typically makes up 94-98% of hemoglobin in adults
- Hemoglobin S: Abnormal hemoglobin type typically found in people with Sickle Cell Disease which causes red blood cells to become misshapen
- Hemoglobin A2: Normal hemoglobin type which typically makes up less than 3% of hemoglobin in adults
If the initial testing shows results that are outside of the normal reference range, additional reflex testing including a Hemoglobin Solubility test will be automatically performed.
A Hemoglobinopathy test may be ordered when a person has symptoms of Hemolytic Anemia such as pale skin, jaundice, lack of energy, or chronic fatigue. This test is also commonly ordered as part of prenatal testing, especially if one or both parents have family members with a hemoglobin abnormality. It may be ordered as a follow-up to abnormal results on a Complete Blood Count (CBC). It may also be ordered when someone has had a positive Hemoglobin Solubility test.
Turnaround for this test is typically 3-5 business days. The turnaround may be longer if reflex testing is necessary.